What is P21?
P21, also written P021, is a small synthetic peptide based on an active region of ciliary neurotrophic factor (CNTF), a protein that supports nerve cells. It carries an adamantane-based amino acid at its end, a fatty group that helps it cross the blood-brain barrier. It was developed by Khalid Iqbal’s group at the New York State Institute for Basic Research and has been studied in mouse models of Alzheimer’s disease and Down syndrome.
P21 is not related to the cell-cycle protein also called p21 (CDKN1A).
P21 product specifications
- Compound: P21 (P021)
- Structure: Ac-Asp-Gly-Gly-Leu-adamantylglycine-NH2 (acetylated and amidated)
- Molecular formula: C27H42N6O8
- Molecular weight: about 578.7 g/mol
- Vial size: 5mg
Regulatory status
P21 is not an approved medicine in the US, UK, EU or Canada and has no published human clinical trials. This product is sold for laboratory research use only.
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Handling and research-use notice
Store and handle this material as stated on the label and certificate of analysis for your batch; see our guide to storing research peptides. This product is sold for laboratory research use only. It is not a medicine or supplement and is not for human or veterinary use.
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