What is Dihexa?
Dihexa, also known as PNB-0408, is a small synthetic compound developed at Washington State University from research on angiotensin IV. It is often called a peptide, but it is more accurately a peptidomimetic: a molecule built to copy features of a peptide while resisting breakdown. Its chemical name is N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide.
Early animal and cell studies from the group that developed it proposed that Dihexa acts through the hepatocyte growth factor (HGF)/c-Met pathway and affects the formation of connections between nerve cells. In 2021 the Journal of Pharmacology and Experimental Therapeutics placed expressions of concern on four of that group’s key papers, citing possible image manipulation. The proposed mechanism should therefore be treated as unconfirmed until it is independently replicated.
Dihexa product specifications
- Compound: Dihexa (PNB-0408)
- Type: angiotensin IV-derived peptidomimetic
- Molecular formula: C27H44N4O5
- Molecular weight: about 504.7 g/mol
- CAS number: 1401708-83-5
- Vial sizes: 5mg, 10mg, 20mg or 50mg
Regulatory status
Dihexa is not an approved medicine in the US, UK, EU or Canada, and there are no published human clinical studies of its safety or effects. This product is sold for laboratory research use only.
Related research peptides
- P21 is another compound studied in mouse models of neurodegeneration.
- Semax and Selank are short peptides studied in neuroscience research.
Available sizes: 5mg, 10mg, 20mg and 50mg
Dihexa is offered in four vial sizes: 5mg, 10mg, 20mg and 50mg. Every size contains the same compound. The figure is the total amount of Dihexa in the vial, supplied as a dry powder; it is not a concentration. A concentration only exists once a lab dissolves the powder, and it depends on how much solvent is used, so a larger vial is not “stronger”, it simply holds more material. The 50mg vial holds ten times as much as the 5mg vial.
Choose the size from the options on this page, then contact us on Telegram or by email for availability.
Handling and research-use notice
Store and handle this material as stated on the label and certificate of analysis for your batch; see our guide to storing research peptides. This product is sold for laboratory research use only. It is not a medicine or supplement and is not for human or veterinary use.
