What is Matrixyl?
Matrixyl is the trade name, owned by the French ingredient maker Sederma, for palmitoyl pentapeptide-4. It is the five-amino-acid peptide Lys-Thr-Thr-Lys-Ser (KTTKS) with a palmitic acid chain attached, which makes it more fat-soluble. It is classed as a matrikine: a small peptide fragment related to proteins of the extracellular matrix.
Product specifications
- Compound: palmitoyl pentapeptide-4
- Sequence: Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS)
- Molecular formula: C39H75N7O10
- Molecular weight: about 802.1 g/mol
- CAS number: 214047-00-4
- Amounts: 10mg and 200mg
Matrixyl vs Matrixyl 3000
Matrixyl 3000 is a different Sederma ingredient that combines two other peptides: palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR). Both are available separately.
Related cosmetic peptides
- Syn-Coll (palmitoyl tripeptide-5) and Lipopeptide (palmitoyl hexapeptide-12) are other palmitoylated peptides.
- Read our overview of top cosmetic peptides.
Available sizes: 10mg and 200mg
Matrixyl is offered in two amounts: 10mg and 200mg. Both are the same raw material; the figure is the total amount of peptide supplied, not a concentration. Choose the amount that fits your formulation or research work, and tell us which you need when you contact us on Telegram or by email.
Research-use notice
This material is sold as a raw ingredient for cosmetic formulation and laboratory research. It is not a finished cosmetic or medicine and is not for direct human use. Store and handle it as stated on the label and certificate of analysis; see our guide to storing research peptides.



